Sleep apnea is a disorder that causes people to stop breathing while asleep. This happens either because of blockage of an airway or because the brain does not correctly control breathing [1].

Recent studies have indicated that certain dietary patterns may influence the likelihood of developing sleep apnea [2,3]. The connection between diet and sleep apnea is complex and multifaceted. Factors such as excessive weight, inflammation, and metabolic dysfunction are believed to interact with dietary choices and contribute to the development and severity of sleep apnea [4-6]. While there is growing interest in the potential link between dietary patterns and sleep apnea, it is important to recognize that there is currently no consensus in the scientific community regarding the impact of diet on the development and severity of sleep apnea. Some studies have suggested that certain dietary patterns, such as a high intake of calories, salt, and Mediterranean dietary intervention may be associated with an increased risk of sleep apnea [7-12]. However, the current body of research remains insufficient, particularly in terms of the number of studies and the availability of observational data for conducting randomized controlled trials (RCTs). Additionally, research on dietary interventions is limited to investigations focusing on the Mediterranean diet [2].

Furthermore, the multifaceted nature of sleep apnea, which involves complex interactions between physiological, anatomical, and behavioral factors, makes it challenging to isolate the specific effects of diet on this sleep disorder [6,13-15].

In this study, we aimed to investigate the relationship between dietary patterns, as measured by the Recommended Food Score (RFS), and the risk of sleep apnea, as assessed using the Berlin Questionnaire (BQ). By examining these factors, we hope to determine the potential influence of diet on sleep apnea and contribute to the development of dietary interventions for individuals at risk.

Table 1 presents an analysis and description of the characteristics of the study subjects. The majority of the participants were under the age of 50, and a significant proportion held college degrees. Sex differences were also observed. Males were more likely to smoke, consume alcohol, and exhibit greater blood pressure than females. Additionally, differences were noted in liver function test results between males and females.

Table 2 shows the associations between various variables, including the RFS (odds ratio [OR]=0.91 [95% confidence interval, 0.82–1.00, P=0.048]), sex, age, education, marital status, income, smoking status, alcohol consumption status, exercise status, fasting blood sugar, and blood pressure, and the BQ score in the low- and high-risk categories. ORs are provided for both univariable and multivariable analyses.

While the RFS did not exhibit statistical significance in the univariate analysis of the BQ score, a statistically significant negative correlation emerged when adjusted for other factors. Moreover, significant correlations were observed with sex, age, education level, current smoking status, alcohol consumption, and engagement in exercise above moderate intensity. Metabolic syndrome parameters, including blood pressure, waist circumference, and triglyceride levels, also showed a positive correlation with BQ categories. In the hematologic marker analysis, significant differences were noted in C-reactive protein (CRP) levels and liver function test results (Table 2).

The OR of the BQ tended to be less than 1 when the RFS, the primary variable of this study, belonged to the group with a score of 23 or higher. Moreover, the OR tended to be greater in males, while it decreased with older age and higher educational attainment. Current smoking and alcohol consumption of more than two drinks per day were associated with increased OR values, whereas engaging in moderate-intensity exercise was linked to lower OR values. Variables related to metabolic syndrome, CRP levels, and glutamic pyruvic transaminase (GPT) also demonstrated statistically significant associations, with higher values (Fig. 2).

This study investigated the association between dietary patterns and sleep apnea risk and revealed a negative correlation between a higher RFS and sleep apnea risk.

Consistent with previous literature, sex and education level also showed significant associations with sleep quality. Males tended to have greater odds of exhibiting sleep-disordered breathing, while higher educational attainment appeared to be protective against these symptoms. These findings align with existing research on the demographic factors influencing sleep patterns and sleep disorders [20].

In addition to diet quality, lifestyle factors such as smoking and alcohol consumption demonstrated associations with sleep quality. Current smoking and frequent alcohol consumption were linked to elevated odds of sleep-disordered breathing, highlighting the detrimental impact of these habits on sleep quality [13-15]. Conversely, engagement in moderate-intensity exercise has been shown to have a protective effect against sleep apnea symptoms [6].

Furthermore, the study revealed positive correlations between metabolic syndrome components, particularly blood pressure, waist circumference, and triglyceride levels, and the risk of sleep-disordered breathing. This shows the interconnection of metabolic health and sleep quality, emphasizing the importance of addressing underlying metabolic factors in the management of sleep disorders [21,22].

Notably, hematologic markers, including CRP levels and GPT, displayed significant associations with sleep quality, indicating potential links between inflammation, liver function, and sleep disturbances. These findings warrant further investigation into the mechanistic pathways underlying these associations and their implications for clinical management [23,24].

Several hypotheses can be considered regarding the possible mechanisms underlying the association between dietary quality and sleep apnea. First, the composition of a nutrient-rich, high-quality diet may play a role in promoting overall health, including improvements in sleep quality [3]. Second, a high-quality diet may act as a predisposing factor related to metabolic syndrome or weight management [21]. Additionally, these dietary patterns have been associated with antioxidant activity, which could influence sleep health, along with changes in the composition of intestinal microorganisms [25,26] (Fig. 3). Finally, other lifestyle factors also contribute to the complex interaction between diet and sleep health [27-29].

In this study, univariate analysis revealed a correlation between increasing age and a greater risk of developing sleep apnea, reflecting the elevated prevalence of this condition among older age groups. This observation aligns with the general understanding that advancing age is associated with physiological changes, including decreased muscle tone, increased fatty tissue around the airway, and decreased respiratory function. These age-related changes can collectively contribute to the development of obstructive sleep apnea [30]. However, as demonstrated in this study, when health-related variables that may vary with age are included and analyzed, age alone does not emerge as an independent risk factor for sleep apnea. This finding suggests that physiological changes associated with aging, such as increased blood pressure and alterations in waist circumference, as well as health behaviors such as smoking, drinking, and exercise, may play more significant roles in the onset of sleep apnea than age itself. With the inclusion of several clinical variables that are influenced by age in the analysis, age may have diminished significance in the occurrence of sleep apnea.

The strength of this study lies in its ability to enhance generalizability through the recruitment of a substantial number of visitors from the actual health center. Additionally, the inclusion of hematologic markers, such as CRP levels and liver function test results, provides depth to the study’s findings by revealing potential links between inflammation, liver function, and sleep disturbances. These associations contribute to a holistic assessment of factors influencing sleep health, thereby expanding the study’s scope beyond traditional dietary and lifestyle measures. Moreover, the recognition of significant factors such as sex, age, education level, smoking status, alcohol consumption, and engagement in exercise demonstrates the comprehensive consideration of various determinants of sleep-disordered breathing. This comprehensive approach offers valuable insights into the multifactorial nature of sleep disorders and highlights the interconnectedness of demographic, behavioral, and metabolic factors.

One notable limitation is the cross-sectional nature of the study, which limits establishing causality between diet quality and sleep-disordered breathing. Longitudinal studies are needed to understand the temporal relationships and causal pathways underlying these associations. In particular, the correlation between metabolic syndrome components, blood test results, and sleep apnea can present a reverse causality issue. For example, poor sleep quality can exacerbate metabolic components or blood test levels. To address this reverse causality problem, additional cohort studies or RCTs that can establish causality will be needed in the future.

Additionally, the reliance on self-reported data for dietary intake, lifestyle behaviors, and sleep quality may introduce measurement biases and potential inaccuracies. The subjective nature of self-reports could lead to misclassification and underestimation of certain factors, impacting the robustness of the findings. Furthermore, while the study adjusted for various confounding factors, the presence of unmeasured or residual confounders cannot be completely ruled out. These unaccounted variables may introduce biases and influence the observed associations between diet, lifestyle, metabolic health, and sleep quality. The generalizability of the findings may also be limited, as the study sample may not fully represent the broader population. Bias may arise from targeting a relatively healthy population visiting the health examination center. Moreover, this study thoroughly examined the connections between dietary patterns, lifestyle behaviors, metabolic factors, and sleep quality. However, further research is needed to explore the underlying mechanistic pathways of these interrelationships. Understanding the connections between diet, metabolism, and sleep disturbances is essential for a comprehensive understanding of their associations. Despite these limitations, the study’s findings contribute to the existing knowledge base and provide a foundation for future research endeavors aiming to unravel the intricacies of the relationship between diet, lifestyle, metabolic health, and sleep quality. Addressing these limitations through longitudinal, mechanistic studies and improved measurement methods will be essential for advancing our understanding and enhancing the clinical implications of the observed associations.

In conclusion, this study sheds light on the association between diet and sleep apnea, emphasizing the importance of further investigating the mechanical pathway underlying this association.