Risk Factors of Colorectal Polyps in Jeju Island
- Mira Um1, Mi Hee Kong1,2, Hyeon Ju Kim1,2,, Yeoun Ja Na1
- Received March 26, 2014 Accepted November 26, 2014
- ABSTRACT
-
- Background
- The incidence of colorectal polyps have been reported to be increasing in those aged 30–40 years who consume fast food, have low physical activity, and use alcohol and cigarettes. We analyzed the characteristics and risk factors of colorectal polyps in asymptomatic adults in Jeju Island.
- Methods
- Data on 1700 individuals who underwent a screening colonoscopy from 1 July, 2010 to 30 June, 2012 were analyzed based on age, gender, body mass index (BMI), blood pressure, blood tests, and behavioral habits including alcohol use, smoking, and exercise.
- Results
- The prevalence of colorectal polyps, including adenomatous and hyperplastic, is 43.1% and is higher in males (P<0.001). The prevalence according to age group shows increasing by age (P for trend<0.001). The most common histologic type of polyp is adenomatous in the <50 years and >50 years age groups, 27.3% and 45.3% respectively. And the percentage of adenomatous polyps has shown an increasing trend along with increasing number and size of polyps (P for trend<0.001). BMI, waist circumference (WC), fasting blood sugar, and triglyceride were higher in males with polyps than males in the control group. BMI and WC were higher and HDL-cholesterol was lower in females with polyps. The incidence of colorectal polyps was higher in male and female smokers (P<0.001 and P=0.035 respectively).
- Conclusions
- Our results showed that older age, male gender, obesity, and smoking are risk factors for colorectal polyps. The prevalence of colorectal adenomatous polyps is 27.3% in <50 yrs, 33.4% in the 40s. For early detection and treatment, we recommend a screening colonoscopy for those with risk factors.
Table 1.
General characteristics of subjects
| Characteristics |
Male (n=1,067) |
Pb |
Female ((n=633) |
Pb | ||
|---|---|---|---|---|---|---|
| Polypsa (n=543) | No (n=524) | Polypsc (n=189) | No (n=444) | |||
| Height, cm | 169.11±5.71 | 170.22±5.87 | 0.513 | 155.90±5.15 | 156.51±5.34 | 0.294 |
| Weight, kg | 73.14±9.86 | 73.35±9.95 | 0.030 | 60.47±8.07 | 57.45±7.96 | <0.001 |
| BMI, kg/m2 | 25.53±2.85 | 25.28±2.85 | 0.033 | 24.87±3.03 | 23.46±3.12 | <0.001 |
| WC, cm | 88.81±7.36 | 87.76±7.44 | 0.025 | 84.39±8.40 | 80.08±8.38 | <0.001 |
| SBP, mmHg | 127.00±13.47 | 126.52±13.48 | 0.705 | 121.22±14.68 | 117.81±14.46 | 0.426 |
| DBP, mmHg | 77.76±9.89 | 77.59±9.97 | 0.933 | 73.46±10.40 | 71.30±9.38 | 0.154 |
| FBS, mg/dL | 99.92±30.36 | 92.91±17.50 | 0.001 | 93.79±19.68 | 90.67±19.28 | 0.249 |
| TC, mg/dL | 198.40±35.09 | 197.45±33.12 | 0.512 | 203.92±35.26 | 197.26±32.30 | 0.222 |
| TG, mg/dL | 141.24±109.41 | 132.02±79.90 | 0.019 | 90.80±50.50 | 82.92±49.28 | 0.649 |
| HDL, mg/dL | 49.80±12.06 | 49.83±11.97 | 0.509 | 57.27±13.00 | 61.33±14.32 | 0.013 |
Table 2.
Age distribution of colorectal polyps and adenoma
| Age, y | Polypsa N (%) | Pb | Adenoma N (%) | Pb |
|---|---|---|---|---|
| 20–29 | 2 (9.1) | <0.001 | 2 (9.1) | <0.001 |
| 30–39 | 108 (28.3) | 76 (19.9) | ||
| 40–49 | 216 (41.0) | 176 (33.4) | ||
| 50–59 | 248 (49.6) | 206 (41.2) | ||
| 60–69 | 137 (58.1) | 122 (51.7) | ||
| 70- | 21 (63.6) | 20 (60.6) | ||
| Total | 732 (43.1) | 602 (35.4) |
Table 3.
Characteristics of colorectal polyps
Table 4.
Multivariate logistic regression analysis of colorectal polyps according to risk factors
|
Male |
Female |
|||
|---|---|---|---|---|
| OR (95% CI) | Pa | OR (95% CI) | Pa | |
| Age, per year | 1.073 (1.056–1.091) | <0.001 | 1.063 (1.035–1.353) | 0.012 |
| BMI, per 1kg/m2 | 1.054 (1.002–1.109) | 0.042 | 1.183 (1.035–1.353) | 0.014 |
| Smokingb | 1.816 (1.349–2.444) | <0.001 | 3.470 (1.088–11.065) | 0.035 |
| Alcoholc | 1.180 (0.884–1.575) | 0.261 | 0.572 (0.184–1.774) | 0.333 |
| Exercised | 0.866 (0.631–1.188) | 0.372 | 1.043 (0.461–2.362) | 0.920 |
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