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The Relationship between Uric Acid and Homocysteine Levels based on Alcohol-related Facial Flushing


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The Relationship between Uric Acid and Homocysteine Levels based on Alcohol-related Facial Flushing

Article information

Korean J Health Promot. 2015;15(3):91-97
Publication date (electronic) : 2015 December 19
doi : https://doi.org/10.15384/kjhp.2015.15.3.91
Eo Chin Kim1, Jong Sung Kim,2, Won Chul Uh1, Soo Young Choi3, Sun Kyung Lee1, Bog Seon Jeong4
1Health Promotion Center, Daejeon St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Daejeon, Korea
2Department of Family Medicine, Chungnam National University Hospital, Chungnam National University School of Medicine, Daejeon, Korea
3Department of Family Medicine, Chungnam National University School of Medicine, Daejeon, Korea
4Department of Family Medicine, Daejeon Veterans Hospital, Daejeon, Korea
￭ Corresponding author：Jong Sung Kim, MD, PhD Department of Family Medicine, Chungnam National University Hospital, Chungnam National University School of Medicine, 282 Munhwa-ro, Jung-gu, Daejeon 35015, Korea Tel: +82-42-280-8172, Fax: +82-42-280-7879 E-mail: jskim@cnuh.co.kr
Received 2015 April 23; Accepted 2015 September 15.

Abstract

Background

This study aimed to determine the correlation between blood uric acid and homocysteine levels, based on alcohol-related facial flushing.

Methods

Among male adults who visited a health examination center of a university hospital located in Daejeon, Korea, for a personal health examination from March 2013 to February 2014, 702 subjects were analyzed including 401 subjects without alcohol-related facial flushing and 301 with facial flushing. Pearson’s correlation and stepwise multivariate linear regression analyses were performed between the log homocysteine levels and other variables including uric acid.

Results

Uric acid showed a significant positive correlation with log homocysteine (γ =0.166, P=0.001) (ß=0.176; P=0.001) in the non-flushing group. In contrast, none of the variables showed any significant correlations with log homocysteine in the flushing group.

Conclusions

Alcohol users not exhibiting alcohol-related facial flushing showed a positive correlation between uric acid and homocysteine levels, whereas those without facial flushing showed no such correlation.

Keywords: Homocysteine; Uric acid; Flushing; Alcohol drinking

Characteristics of study subjectsa

Correlations between log homocysteine and other variables (non adjusted)

Log homocysteine by amount of alcohol

References

1. Iseki K, Ikemiya Y, Inoue T, Iseki C, Kinjo K, Takishita S. Significance of hyperuricemia as a risk factor for developing ESRD in a screened cohort. Am J Kidney Dis 2004;44(4):642–50.
2. Feig DI, Soletsky B, Johnson RJ. Effect of allopurinol on blood pressure of adolescents with newly diagnosed essential hypertension: a randomized trial. JAMA 2008;300(8):924–32.
3. Strasak A, Ruttmann E, Brant L, Kelleher C, Klenk J, Concin H, et al. Serum uric acid and risk of cardiovascular mortality: a prospective long-term study of 83,683 Austrian men. Clin Chem 2008;54(2):273–84.
4. Nakagawa T, Hu H, Zharikov S, Tuttle KR, Short RA, Glushakova O, et al. A causal role for uric acid in fructose-induced metabolic syndrome. Am J Physiol Renal Physiol 2006;290(3):F625–31.
5. Khanna D, Fitzgerald JD, Khanna PP, Bae S, Singh MK, Neogi T, et al. 2012 American College of Rheumatology guidelines for management of gout. Part 1: systematic nonpharmacologic and pharmacologic therapeutic approaches to hyperuricemia. Arthritis Care Res (Hoboken) 2012;64(10):1431–46.
6. Roddy E, Doherty M. Epidemiology of gout. Arthritis Res Ther 2010;12(6):223.
7. Selhub J. Homocysteine metabolism. Annu Rev Nutr 1999;19:217–46.
8. McCully KS. Homocysteine and vascular disease. Nat Med 1996;2(4):386–9.
9. Eikelboom JW, Lonn E, Genest J Jr, Hankey G, Yusuf S. Homocyst(e)ine and cardiovascular disease: a critical review of the epidemiologic evidence. Ann Intern Med 1999;131(5):363–75.
10. Refsum H, Ueland PM, Nygård O, Vollset SE. Homocysteine and cardiovascular disease. Annu Rev Med 1998;49(1):31–62.
11. Nygård O, Vollset SE, Refsum H, Brattström L, Ueland PM. Total homocysteine and cardiovascular disease. J Intern Med 1999;246(5):425–54.
12. Marti F, Vollenweider P, Marques-Vidal PM, Mooser V, Waeber G, Paccaud F, et al. Hyperhomocysteinemia is independently associated with albuminuria in the population-based CoLaus study. BMC Public Health 2011;11:733.
13. Malinow MR, Levenson J, Giral P, Nieto FJ, Razavian M, Segond P, et al. Role of blood pressure, uric acid, and hemorheo-logical parameters on plasma homocyst(e)ine concentration. Atherosclerosis 1995;114(2):175–83.
14. Tsutsumi Z, Moriwaki Y, Yamamoto T, Takahashi S, Hada T, Fukuchi M. Total plasma homocysteine is not increased in Japanese patients with gout. J Rheumatol 2002;29(8):1805–6.
15. Choi ST, Kim JS, Song JS. Elevated serum homocysteine levels were not correlated with serum uric acid levels, but with decreased renal function in gouty patients. J Korean Med Sci 2014;29(6):788–92.
16. Crabb DW, Matsumoto M, Chang D, You M. Overview of the role of alcohol dehydrogenase and aldehyde dehydrogenase and their variants in the genesis of alcohol-related pathology. Proc Nutr Soc 2004;63(1):49–63.
17. Suh HS, Kim JS, Kim SS, Jung JG, Yoon SJ, Ahn JB. Influence of the Flushing Response in the Relationship between Alcohol Consumption and Cardiovascular Disease Risk. Korean J Fam Med 2014;35(6):295–302.
18. Jung JG, Kim JS, Kim YS, Oh MK, Yoon SJ. Hypertension associated with alcohol consumption based on the facial flushing reaction to drinking. Alcohol Clin Exp Res 2014;38(4):1020–5.
19. Keys A, Fidanza F, Karvonen MJ, Kimura N, Taylor HL. Indices of relative weight and obesity. J Chronic Dis 1972;25(6):329–43.
20. National Institute on Alcohol Abuse and Alcoholism. Alcohol screening and brief intervention for youth: A practitioner's guide Rockville, MD: National Institute on Alcohol Abuse and Alcoholism; 2011. [Accessed February 28, 2015]. http://pubs.niaaa.nih.gov/publications/Practitioner/YouthGuide/YouthGuide.pdf.
21. Yokoyama A, Muramatsu T, Ohmori T, Kumagai Y, Higuchi S, Ishii H. Reliability of a flushing questionnaire and the ethanol patch test in screening for inactive aldehyde dehydrogenase-2 and alcohol-related cancer risk. Cancer Epidemiol Biomarkers Prev 1997;6(12):1105–7.
22. Levey AS, Stevens LA, Schmid CH, Zhang YL, Castro AF 3rd, Feldman HI, et al. A new equation to estimate glomerular filtration rate. Ann Intern Med 2009;150(9):604–12.
23. Kim EC, Kim JS, Jung JG, Kim SS, Yoon SJ, Ryu JS. Effect of alcohol consumption on risk of hyperhomocysteinemia based on alcohol-related facial flushing response. Korean J Fam Med 2013;34(4):250–7.
24. Emmerson B. Hyperlipidaemia in hyperuricaemia and gout. Ann Rheum Dis 1998;57(9):509–10.
25. Meigs JB, Jacques PF, Selhub J, Singer DE, Nathan DM, Rifai N, et al. Fasting plasma homocysteine levels in the insulin resistance syndrome: the Framingham offspring study. Diabetes Care 2001;24(8):1403–10.
26. Papezikova I, Pekarova M, Lojek A, Kubala L. The effect of uric acid on homocysteine-induced endothelial dysfunction in bovine aortic endothelial cells. Neuro Endocrinol Lett 2009;30(Suppl 1):112–5.
27. Hayden MR, Tyagi SC. Homocysteine and reactive oxygen species in metabolic syndrome, type 2 diabetes mellitus, and athe-roscleropathy: the pleiotropic effects of folate supplementation. Nutr J 2004;3:4.
28. Nieto FJ, Iribarren C, Gross MD, Comstock GW, Cutler RG. Uric acid and serum antioxidant capacity: a reaction to atherosclerosis? Atherosclerosis 2000;148(1):131–9.
29. Fang J, Alderman MH. Serum uric acid and cardiovascular mortality the NHANES I epidemiologic follow-up study, 1971-1992. National Health and Nutrition Examination Survey. JAMA 2000;283(18):2404–10.
30. Barak AJ, Beckenhauer HC, Tuma DJ. Methionine synthase. a possible prime site of the ethanolic lesion in liver. Alcohol 2002;26(2):65–7.
31. Brecher AS, Lehti MD. A hypothesis linking hypoglycemia, hyperuricemia, lactic acidemia, and reduced gluconeogenesis in al-coholics to inactivation of glucose-6-phosphatase activity by acetaldehyde. Alcohol 1996;13(6):553–7.

Article information Continued

Copyright © 2015 The Korean Society of Health Promotion and Disease Prevention

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Table 1.

Characteristics of study subjectsa

Non-flushing group (n=401) Flushing group (n=301)
Age, y 51.2±9.5 51.7±9.4
Body mass index, kg/m2 25.2±3.2 25.3±2.8
Hypertension 92 (22.9) 69 (22.9)
Diabetes 25 (6.2) 25 (8.3)
Current-smoking 236 (58.9) 165 (54.8)
Drinking amount, drinks/wk 12.5 (4.0-20.0)b 7.5 (2.3-19.8)b
Uric acid, mg/dL 6.4±1.3 6.3±1.3
Homocysteine, μmol/L 11.5 (9.8-13.4) 11.7 (10.3-13.3)
Total-cholesterol, mg/dL 195.8±35.6 191.8±35.8
LDL-C, mg/dL 111.5±30.5 110.0±30.1
HDL-C, mg/dL 48.0 (42.0-54.0)c 46.0 (40.0-52.0)c
Triglyceride, mg/dL 144.0 (95.5-206.0) 138.0 (98.5-202.5)
AST, mg/dL 23.0 (19.0-28.0) 23.0 (20.0-30.0)
ALT, mg/dL 26.0 (20.0-35.0) 27.0 (20.0-39.0)
γ-GTP, mg/dL 31.0 (19.5-60.5) 33.0 (20.0-58.0)
eGFR, mL/min/1.73 m2 92.1 (82.9-104.1) 92.1 (82.6-103.8)

Abbreviations: AST, aspartate aminotransferase; ALT, alanine aminotransferase; γ-GTP, gamma-glutamyl transferase; eGFR, estimated glomerular filtration rate; HDL-C, high density lipoprotein cholesterol; LDL-C, low density lipoprotein cholesterol.

a

Values are presented as N (%) or mean±SD or median expression (interquartile range).

b

<0.001, analysis with Mann-Whitney test or chi-square test (1 drink=alcohol 14 g).

c

<0.05, analysis with Mann-Whitney test or chi-square test.

Table 2.

Correlations between log homocysteine and other variables (non adjusted)

Non-flushing group (n=401) Flushing group (n=301)
r r
Age 0.070 0.043
BMI -0.064 -0.093
Total cholesterol 0.111a 0.019
LDL-C 0.088 -0.004
Log HDL-C 0.068 -0.013
Log TG -0.024 0.045
Uric acid 0.166b 0.087
Log AST 0.038 0.052
Log ALT Log r-GTP -0.055 0.091 -0.085 -0.014

Abbreviations: r, correlation coefficient; BMI, body mass index; AST, aspartate aminotransferase; ALT, alanine aminotransferase; γ -GTP, gamma-glutamyl transferase; HDL-C, high density lipoprotein cholesterol; LDL-C, low density lipoprotein cholesterol; TG, triglyceride.

a

<0.05 analysis of variance with Pearson’s correlation test.

b

<0.01 analysis of variance with Pearson’s correlation test.

Table 3.

Log homocysteine by amount of alcohol

Drinks/wk Non-flushing group (n) Flushing group (n)
≥0.5, <4 2.5±0.3 (84) 2.5±0.2 (102)
≥4, <8 ≥8 2.5±0.2 (70) 2.5±0.3 (247) 2.5±0.3 (62) 2.5±0.2 (137)

Values are presented as mean±SD.