Korean J Health Promot > Volume 19(4); 2019 > Article
Lee, Kim, and An: Current Treatments on Obesity

ABSTRACT

Recently, the number of obesity and diabetes mellitus have increased rapidly not only in Korea but also around the world. It is even called the new pandemic of the 21st century. In Korea, the diabetes growth rate, which exceeds the obesity growth rate, is a bigger problem. Accordingly, the simultaneous treatment of diabetes and obesity has become a global issue. In this article, we will review various obesity treatments to help diabetes remission and take a look at meaningful previous study about dietary methods for obesity. This overview includes the update of medications for obesity and the practical method for clinicians in field of obesity treatment in Korea.

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Figure 1

Increasing prevalence of obesity from 2009 to 2015 in Korea.4)

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Figure 2

Heavy misconceptions about obesity of all over the world.11)

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Figure 3

Remission of type 2 diabetes after primary care for weight management shown by DiRECT study.16) DiRECT, Diabetes Remission Clinical Trial; CI, confidence interval.

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Figure 4

Long-term effects of a novel continuous remote care intervention including nutritional ketosis for the management of type 2 diabetes shown by Low Carb High Fat (LCHF) study for 2 years.17) HbA1c, hemoglobin A1c.

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Figure 5

Association between estimated percentage energy from fat versus carbohydrate and total mortality shown by Prospective Urban Rural Epidemiology (PURE) study.66) HR, hazard ratio.

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Figure 6

(A, B) U-shaped association between percentage of energy from carbohydrate and all-cause mortality in the Atherosclerosis Risk in Communities (ARIC) (line) and Prospective Urban Rural Epidemiology (PURE) (dotted line) cohort studies.67)

kjhp-19-171-g006.jpg
Figure 7

Mechanism of anti-obesity medication about homeostatic appetite and hedonic appetite.81) ARC, arcuate nucleus; GABA, gamma-aminobutyric acid.

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Figure 8

Four large SCALE randomized multicenter phase III trial in liraglutide (SCALE Obesity and Prediabetes, SCALE Diabetes, SCALE Sleep Apnea, and SCALE Maintenance).105,106,107,108)

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